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PLoS By Category | Recent PLoS Articles
Mental Health - Neurological Disorders - Neuroscience - Physiology - Radiology and Medical Imaging

Reduced Gray to White Matter Tissue Intensity Contrast in Schizophrenia
Published: Tuesday, May 15, 2012
Author: Li Kong et al.

by Li Kong, Christina Herold, Bram Stieltjes, Marco Essig, Ulrich Seidl, Robert Christian Wolf, Torsten Wüstenberg, Marc Montgomery Lässer, Lena Anna Schmid, Knut Schnell, Dusan Hirjak, Philipp Arthur Thomann

Background

While numerous structural magnetic resonance imaging (MRI) studies revealed changes of brain volume or density, cortical thickness and fibre integrity in schizophrenia, the effect of tissue alterations on the contrast properties of neural structures has so far remained mostly unexplored.

Methods

Whole brain high-resolution MRI at 3 Tesla was used to investigate tissue contrast and cortical thickness in patients with schizophrenia and healthy controls.

Results

Patients showed significantly decreased gray to white matter contrast in large portions throughout the cortical mantle with preponderance in inferior, middle, superior and medial temporal areas as well as in lateral and medial frontal regions. The extent of these intensity contrast changes exceeded the extent of cortical thinning. Further, contrast changes remained significant after controlling for cortical thickness measurements.

Conclusions

Our findings clearly emphasize the presence of schizophrenia related brain tissue changes that alter the imaging properties of brain structures. Intensity contrast measurements might not only serve as a highly sensitive metric but also as a potential indicator of a distinct pathological process that might be independent from volume or thickness alterations.

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