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PLoS By Category | Recent PLoS Articles
Ecology - Gastroenterology and Hepatology - Microbiology - Pediatrics and Child Health

Diversity of Bifidobacteria within the Infant Gut Microbiota
Published: Friday, May 11, 2012
Author: Francesca Turroni et al.

by Francesca Turroni, Clelia Peano, Daniel A. Pass, Elena Foroni, Marco Severgnini, Marcus J. Claesson, Colm Kerr, Jonathan Hourihane, Deirdre Murray, Fabio Fuligni, Miguel Gueimonde, Abelardo Margolles, Gianluca De Bellis, Paul W. O’Toole, Douwe van Sinderen, Julian R. Marchesi, Marco Ventura

Background

The human gastrointestinal tract (GIT) represents one of the most densely populated microbial ecosystems studied to date. Although this microbial consortium has been recognized to have a crucial impact on human health, its precise composition is still subject to intense investigation. Among the GIT microbiota, bifidobacteria represent an important commensal group, being among the first microbial colonizers of the gut. However, the prevalence and diversity of members of the genus Bifidobacterium in the infant intestinal microbiota has not yet been fully characterized, while some inconsistencies exist in literature regarding the abundance of this genus.

Methods/Principal Findings

In the current report, we assessed the complexity of the infant intestinal bifidobacterial population by analysis of pyrosequencing data of PCR amplicons derived from two hypervariable regions of the 16 S rRNA gene. Eleven faecal samples were collected from healthy infants of different geographical origins (Italy, Spain or Ireland), feeding type (breast milk or formula) and mode of delivery (vaginal or caesarean delivery), while in four cases, faecal samples of corresponding mothers were also analyzed.

Conclusions

In contrast to several previously published culture-independent studies, our analysis revealed a predominance of bifidobacteria in the infant gut as well as a profile of co-occurrence of bifidobacterial species in the infant’s intestine.

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