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Immunology - Public Health and Epidemiology - Respiratory Medicine - Rheumatology


Association of Human Leukocyte Antigen with Interstitial Lung Disease in Rheumatoid Arthritis: A Protective Role for Shared Epitope
Published: Monday, May 07, 2012
Author: Hiroshi Furukawa et al.

by Hiroshi Furukawa, Shomi Oka, Kota Shimada, Shoji Sugii, Jun Ohashi, Toshihiro Matsui, Tatsuoh Ikenaka, Hisanori Nakayama, Atsushi Hashimoto, Hirokazu Takaoka, Yoshiyuki Arinuma, Yuko Okazaki, Hidekazu Futami, Akiko Komiya, Naoshi Fukui, Tadashi Nakamura, Kiyoshi Migita, Akiko Suda, Shouhei Nagaoka, Naoyuki Tsuchiya, Shigeto Tohma

Introduction

Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association with RA have been reported, but few have been validated in an RA subpopulation with ILD. In this study, we investigated the association of HLA class II alleles with ILD in RA.

Methods

An association study was conducted on HLA-DRB1, DQB1, and DPB1 in 450 Japanese RA patients that were or were not diagnosed with ILD, based on the findings of computed tomography images of the chest.

Results

Unexpectedly, HLA-DRB1*04 (corrected P [Pc]?=?0.0054, odds ratio [OR] 0.57), shared epitope (SE) (P?=?0.0055, OR 0.66) and DQB1*04 (Pc?=?0.0036, OR 0.57) were associated with significantly decreased risk of ILD. In contrast, DRB1*16 (Pc?=?0.0372, OR 15.21), DR2 serological group (DRB1*15 and *16 alleles) (P?=?0.0020, OR 1.75) and DQB1*06 (Pc?=?0.0333, OR 1.57, respectively) were significantly associated with risk of ILD.

Conclusion

HLA-DRB1 SE was associated with reduced, while DR2 serological group (DRB1*15 and *16) with increased, risk for ILD in Japanese patients with RA.

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