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Hematology - Pediatrics and Child Health

X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis
Published: Wednesday, April 18, 2012
Author: Libing Wang et al.

by Libing Wang, Fan Yin, Xia Xu, Xiaoxia Hu, Dongbao Zhao


Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effects of XRCC1 variants on childhood ALL risk.


A meta-analysis was performed to examine the association between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and childhood ALL risk. We critically reviewed 7 studies with a total of 880 cases and 1311 controls for Arg399Gln polymorphism, 3 studies with a total of 345 cases and 554 controls for Arg280His polymorphism, and 6 studies with a total of 783 cases and 1180 controls for Arg194Trp polymorphism, respectively. Odds ratio (OR) and its 95% confidence interval (CI) were used.


Significant association between XRCC1 Arg399Gln polymorphism and childhood ALL risk was observed in total population analyses (ORadditive model?=?1.501, 95% CI 1.112–2.026, POR?=?0.008; ORdominant model?=?1.316, 95% CI?=?1.104–1.569, POR?=?0.002) and Asian subgroup analyses (ORadditive model?=?2.338, 95%CI?=?1.254–4.359, POR?=?0.008; ORdominant model?=?2.108, 95%CI?=?1.498–2.967, POR?=?0.000). No association was detected in Caucasians, Metizo and mixed populations. Ethnicity was considered as a significant source of heterogeneity in the meta-regression model. For the other two XRCC1 polymorphisms, no association with childhood ALL risk was found.


The meta-analysis results suggested that XRCC1 Arg399Gln polymorphism might be associated with elevated childhood ALL risk among Asian population.