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PLoS By Category | Recent PLoS Articles
Nephrology

Electrocardiographic Left Ventricular Hypertrophy and Outcome in Hemodialysis Patients
Published: Tuesday, April 17, 2012
Author: Seung Jun Kim et al.

by Seung Jun Kim, Hyung Jung Oh, Dong Eun Yoo, Dong Ho Shin, Mi Jung Lee, Hyoung Rae Kim, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Kyu Hun Choi, Shin-Wook Kang

Background and Aims

Electrocardiography (ECG) is the most widely used initial screening test for the assessment of left ventricular hypertrophy (LVH), an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). However, traditional ECG criteria based only on voltage to detect LVH have limited clinical utility for the detection of LVH because of their poor sensitivity.

Methods

This prospective observational study was undertaken to compare the prognostic significance of commonly used ECG criteria for LVH, namely Sokolow-Lyon voltage (SV) or voltage-duration product (SP) and Cornell voltage (CV) or voltage-duration product (CP) criteria, and to investigate the association between echocardiographic LV mass index (LVMI) and ECG-LVH criteria in ESRD patients, who consecutively started maintenance hemodialysis (HD) between January 2006 and December 2008.

Results

A total of 317 patients, who underwent both ECG and echocardiography, were included. Compared to SV and CV criteria, SP and CP criteria, respectively, correlated more closely with LVMI. In addition, CP criteria provided the highest positive predictive value for echocardiographic LVH. The 5-year cardiovascular survival rates were significantly lower in patients with ECG-LVH by each criterion. In multivariate analyses, echocardiographic LVH [adjusted hazard ratio (HR): 11.71; 95% confidence interval (CI): 1.57–87.18; P?=?0.016] and ECG-LVH by SP (HR: 3.43; 95% CI: 1.32–8.92; P?=?0.011) and CP (HR: 3.07; 95% CI: 1.16–8.11; P?=?0.024) criteria, but not SV and CV criteria, were significantly associated with cardiovascular mortality.

Conclusions

The product of QRS voltage and duration is helpful in identifying the presence of LVH and predicting cardiovascular mortality in incident HD patients.

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