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Anesthesiology and Pain Management - Critical Care and Emergency Medicine - Immunology - Physiology


The Axonal Guidance Receptor Neogenin Promotes Acute Inflammation
Published: Tuesday, March 06, 2012
Author: Klemens König et al.

by Klemens König, Dimitra Gatidou, Tiago Granja, Jens Meier, Peter Rosenberger, Valbona Mirakaj

Neuronal guidance proteins (NGP) were originally described in the context of axonal growth and migration. Yet recent work has demonstrated that NGPs also serve as guidance cues for immune competent cells. A crucial target receptor for NGPs during embryonic development is the neogenin receptor, however its role during acute inflammation is unknown. We report here that neogenin is abundantly expressed outside the nervous system and that animals with endogenous repression of neogenin (Neo1-/-) demonstrate attenuated changes of acute inflammation. Studies using functional inhibition of neogenin resulted in a significant attenuation of inflammatory peritonitis. In studies employing bone marrow chimeric animals we found the hematopoietic presence of Neo1-/- to be responsible for the attenuated inflammatory response. Taken together our studies suggest that the guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.
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