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Immunology - Pharmacology

The Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti-Inflammatory Drugs
Published: Monday, November 12, 2012
Author: José A. G. Agúndez et al.

by José A. G. Agúndez, Pedro Ayuso, José A. Cornejo-García, Miguel Blanca, María J. Torres, Inmaculada Doña, María Salas, Natalia Blanca-López, Gabriela Canto, Carmen Rondon, Paloma Campo, José J. Laguna, Javier Fernández, Carmen Martínez, Elena García-Martín

Conclusions and implications

The DAO polymorphism rs10156191 which causes impaired metabolism of circulating histamine is associated with the clinical response in crossed-hypersensitivity to NSAIDs and could be used as a biomarker of response.