News | News By Subject | News by Disease News By Date | Search News
Get Our FREE
Industry eNewsletter

Wyeth Pharmaceuticals (New Jersey) (WYE) Initiates Phase II And Pays Ablynx Another Milestone of $4 Million In The Tnf-Alpha Nanobody(R) Collaboration

9/30/2009 10:24:26 AM

GHENT, BELGIUM--(Marketwire - September 30, 2009) - Ablynx [Euronext Brussels: ABLX], today announced that it has reached a second milestone under the terms of its collaboration with Wyeth Pharmaceuticals, a division of Wyeth. A milestone payment of $4 million has been triggered by the initiation by Wyeth of a first Phase II multiple dose study in patients with rheumatoid arthritis (RA) for a Nanobody® targeting tumour necrosis factor alpha (TNF-alpha).

Wyeth entered into a Phase I study in healthy volunteers in December 2008 in the USA and Japan. Based on a successful conclusion of that study, where the Nanobody® was safe and well tolerated, Wyeth has today initiated a multiple dose Phase II study in RA patients. Ablynx entered into an exclusive research collaboration and license agreement with Wyeth Pharmaceuticals in November 2006, a deal potentially worth $212.5 million for the successful development and commercialisation of multiple products. In addition, Ablynx is eligible to receive royalties on product sales. Wyeth has exclusive rights to develop and commercialise anti-TNF-alpha Nanobodies® developed under the collaboration. TNF-alpha is a key drug target in combating inflammation related disorders such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis and ankylosing spondylitis.

Dr Edwin Moses, CEO and Chairman of Ablynx commented: "After a successful Phase I study in healthy volunteers in the USA and Japan, we are delighted that Wyeth has progressed the TNF-alpha programme into a Phase II study in patients with RA. Therapeutics targeting TNF-alpha generated $16.8 billion in sales in 2008, and Wyeth Pharmaceuticals is well positioned with its Enbrel franchise to progress this Nanobody® programme towards the market and create another great success."

-ends- For more information, please contact: For international media enquiries: College Hill Life Sciences Sue Charles, Justine Lamond, Dr John McIntyre t: +44 (0)20 7866 7857 e: Ablynx: Dr Edwin Moses Chairman and CEO t: +32 (0)9 262 00 07 m: +44 (0)7771 954 193 e: Eva-Lotta Allan Chief Business Officer t: +32 (0)9 262 00 75 m: +32 (0)475 78 36 21 / +44 (0)7990 570 900 e:

This announcement was originally distributed by Hugin. The issuer is solely responsible for the content of this announcement.


Complete version of the press release in English --

Copyright © Hugin AS 2009. All rights reserved.

Read at

comments powered by Disqus