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Unusual Mechanism of DNA Synthesis Could Explain Genetic Mutations, Georgia Institute of Technology Study


9/12/2013 6:08:46 AM

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Researchers have discovered the details of how cells repair breaks in both strands of DNA, a potentially devastating kind of DNA damage. When chromosomes experience double-strand breaks due to oxidation, ionizing radiation, replication errors and certain metabolic products, cells utilize their genetically similar chromosomes to patch the gaps via a mechanism that involves both ends of the broken molecules. To repair a broken chromosome that lost one end, a unique configuration of the DNA replication machinery is deployed as a desperation strategy to allow cells to survive, the researchers discovered.

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