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University of California, Irvine Researchers Demonstrate Drug Candidate ShK-186, Derived From Sea Anemone Venom, Effective in Anti-Obesity Studies



5/28/2013 11:19:33 AM

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IRVINE, Calif. & SEATTLE--(BUSINESS WIRE)--Scientists at UC Irvine reported this week that a synthetic compound ShK-186, originally derived from a sea anemone toxin, has been found to enhance metabolic activity and shows potential as a treatment for obesity and insulin resistance. The findings, published the week of May 27 in the Proceedings of the National Academy of Sciences, reveal that ShK-186 selectively blocks the activity of a protein that promotes inflammation through the Kv1.3 potassium channel. The study presents the first evidence that the drug candidate – which in March showed positive results in a Phase 1 safety clinical trial – may also work in an anti-obesity capacity.

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