BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Trillium Therapeutics Inc.'s Cancer Stem Cell Program to be Highlighted at American Society of Hematology


12/2/2010 1:25:14 PM

Toronto, Canada – December 2, 2010 - Trillium Therapeutics Inc. (TTI), a biopharmaceutical company developing innovative immune-based biologics, today announced that preliminary results from its cancer stem cell program, targeting the CD47 protein, will be reported in an oral presentation at the 52nd American Society of Hematology (ASH) Annual Meeting to be held in Orlando, Florida, December 4-7, 2010. The presentation, entitled "Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRP?”, will take place at 2:45 PM on Monday December 6 in room 308. The work was conducted in the laboratories of Trillium collaborators Drs. John Dick and Jean Wang at University Health Network, and Dr. Jayne Danska at The Hospital for Sick Children, in Toronto, Ontario, and will be presented by Dr. Alexandre Theocharides.

Over expression of CD47 by leukemic stem cells is thought to deliver an inhibitory signal through the SIRP??receptor on macrophages, allowing the cancer cells to escape phagocytosis. Trillium is developing an antagonizing SIRP?Fc fusion protein that blocks this inhibitory signal, allowing host macrophages to attack the cancer.

“Trillium, through its CD200Fc and CD200 antibody programs, has a longstanding interest in immune regulation”, commented Trillium’s Vice President, R&D, Dr. Bob Uger. “The SIRP?Fc program allows us to extend this expertise into the field of leukemic stem cells, which have emerged as important targets in the search for more effective cancer treatments. We will continue to work closely with our academic colleagues to move this program forward and secure a third-party development partner.”

About Trillium:

Trillium Therapeutics Inc. is a private biopharmaceutical company specializing in innovative therapies of immune-mediated conditions, such as autoimmune and inflammatory disorders, as well as cancer. Trillium has a broad portfolio of preclinical immunology programs, including two partnered programs that target the CD200 immunoregulatory axis; a CD200-specific monoclonal antibody for the treatment of cancer, and a CD200Fc fusion protein for the treatment of autoimmune and inflammatory diseases. In addition, the company is developing a SIRP? agonist that activates the CD47-SIRP? axis, suppressing macrophage activation. This agent is being developed to improve human hematopoietic stem cell engraftment, accelerate blood cell recovery post-transplantation, and enable engraftment with lower doses of stem cells (e.g. from cord blood). The company is also developing a SIRP?Fc fusion protein, a decoy receptor that blocks the CD47-SIRP? axis resulting in macrophage activation. This product is initially being developed as a treatment for acute myeloid leukemia. The company’s most advanced program, TTI-1612, is a cytoprotective recombinant growth factor that is being developed for the treatment of interstitial cystitis (IC) and the prevention of necrotizing enterocolitis (NEC). Trillium has a broad network of external academic and industry R&D collaborations, including several license agreements with major US biotechnology companies. The Company is supported by three premier Canadian venture capital investors: Vengrowth Private Equity Partners, Growthworks Capital and BDC Capital.

For more information, please contact:

Niclas Stiernholm, Ph.D. Chief Executive Officer Trillium Therapeutics Inc. 96 Skyway Avenue Toronto, Ontario, M9W 4Y9 Canada

Tel: (416) 595-0627 Fax: (416) 595-5835 niclas@trilliumtherapeutics.com www.trilliumtherapeutics.com



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES