LEXINGTON, Ky., July 17, 2012 /PRNewswire/ -- Transposagen announced that XTN site-specific nucleases targeting each gene in the human genome are now available. Utilizing the FLASH high-throughput system (FLASH assembly of TALENs for high-throughput genome editing. Nature Biotechnology 30, 460-465 (2012)), Transposagen can produce a site-specific nuclease targeting nearly any gene in any genome with the fastest delivery time in the industry. The XTN site-specific nucleases, also referred to as TALENs, permit researchers to specifically cut any DNA sequence, allowing for the creation of gene knockouts, knock-ins and single base pair edits. Researchers can now search Transposagen's GENOME discovery database to choose any target. Transposagen will also perform custom cell line engineering and animal model creation using the XTN technology.
The XTN technology can be used in conjunction with Transposagen's other core technology, piggyBac, as the only system in the world that allows for Footprint-Free genetic engineering down to a single base pair (Bradley et al. Nature 2011). "Researcher's now have the ability to change a single base-pair or multiple base pairs in any genome without residual unwanted changes, such as the addition of a marker gene or recombinase site," said Eric Ostertag, President and CEO of Transposagen. The Footprint-Free genetic engineering system is expected to have applicability in the generation of cell lines and model organisms for functional genomics and the validation of genome-wide association studies (GWAS).
Transposagen is now offering XTN site-specific nucleases worldwide. Custom and off-the-shelf XTN reagents are available through Transposagen (http://www.transposagenbio.com/rats/xtn-tal-nucleases.html) and with the following distributors:
GENTAUR Molecular Products
APRO Life Science Institute Inc. - Japan
MJS Biolynx Inc. Canada
DPC/LEBANON sarl Middle East
BioCat GmBh Germany, Austria & Switzerland
About Transposagen Biopharmaceuticals, Inc.
Transposagen Biopharmaceuticals, Inc., a Lexington, KY-based company, is a worldwide leader in technologies and services for genetic modification. Transposagen is dedicated to providing better disease models through genetic modification. Transposagen specializes in custom and off-the-shelf XTN site-specific nucleases, animal models, cell lines, stem cells and cutting-edge research tools and technologies to improve drug discovery and development research. These unique technologies and services for genetic modification give customers the ability to create nearly any genetic modification in any genome for both research and protein production purposes.
SOURCE Transposagen Biopharmaceuticals, Inc.