Tolera Therapeutics, Inc. Honored as One of the 2010 'Michigan 50 Companies to Watch'

KALAMAZOO, Mich., April 7 /PRNewswire/ -- Tolera Therapeutics has been recognized as one of the 2010 "Michigan 50 Companies to Watch," an awards program sponsored by the Edward Lowe Foundation and presented by Michigan Celebrates Small Business.

Tolera is a Kalamazoo, Michigan based clinical stage company with a highly specific T-cell targeting monoclonal antibody technology (anti-TCR) for immune modulation. This technology has broad application potential in T-cell mediated disease such as transplant rejection, autoimmune disease (e.g. type 1 diabetes and multiple sclerosis) and hematological malignancies (e.g. leukemia). Tolera will initiate Phase 2 human clinical trials this summer for its lead drug candidate TOL101.

"Now 300 strong, the second-stage businesses that comprise the Michigan 50 Companies to Watch have not only persevered through challenging times, but also found opportunities to grow," says Penny Lewandowski, director of entrepreneurship development at the Edward Lowe Foundation. "They continue to hire and develop new markets for their products and services. Some have attracted significant amounts of venture capital, while others have been awarded prestigious federal grants. They are making a substantial difference in their communities -- and their industries. Our 2010 inductees are proof that entrepreneurs are, and always have been, the future of Michigan's economy."

Winners were selected by Michigan-based judges from the banking, economic development, entrepreneurship development and venture capital communities.

PNC Bank is the lead underwriter for Michigan Celebrates Small Business, with additional underwriting support from Clark Hill PLC, Michigan Economic Development Corporation, Michigan Certified Development Corporation, Accident Fund Insurance Company of America, Comcast Business Class, Comcast Spotlight, and Dynamic Edge.

Information about the 2010 Michigan 50 Companies to Watch program can be found at http://Michigan.CompaniesToWatch.org. For information about Michigan Celebrates Small Business, visit http://MichiganCelebrates.biz.

Tolera Therapeutics

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