LOUGHBOROUGH, England (23rd July, 2012) – Thermo Fisher Scientific Inc., the world leader in serving science, has published a white paper entitled “Optimizing mobile phase solvent purity for LC/MS.” Enhanced sensitivity and mass accuracy in liquid chromatography/mass spectroscopy (LC/MS) is essential when analytes are found in trace amounts. Purity is a crucial consideration when selecting appropriate solvents for use in such analyses, where background noise must be minimal. Optimizing the quality of mobile phase solvents can contribute to improving the chromatographic or mass spectroscopic properties of the analyte, as well as the overall detection limits of the instrument system. The whitepaper highlights the low mass background, metal ion content, contamination and LC/UV response, using diode array detection, that is possible when using the Fisher Chemical Optima LC/MS solvent range instead of other solvent brands.
Examining LC/MS solvents offered by seven companies, including Thermo Fisher, the white paper presents comparative chromatographic data from four different advanced LC/MS instruments. Data collected includes mass baseline, signal intensity, contamination by PEG and plasticizers, and metal ion content, all of which impact on the ease of MS interpretation. This data suggests that the Optima LC/MS solvent range is best for mobile phase purity.
Optima LC/MS solvents are manufactured and packaged using proprietary techniques to ensure exceptionally low metal ion content and minimal MS background noise. They also offer lot-to-lot consistency and extended column life due to low residue levels, setting the standard of excellence for consistent, reproducible performance in the mobile phase of advanced LC/MS systems.
The white paper can be downloaded at: http://www.thermo.com/eThermo/CMA/PDFs/Various/File_52953.pdf.
For more information on the Optima LC/MS reagents and other Fisher Chemical products, please visit www.acros.com or contact a local Fisher Chemical distributor.
About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of $12 billion, we have approximately 39,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through three premier brands, Thermo Scientific, Fisher Scientific and Unity™ Lab Services, which offer a unique combination of innovative technologies, convenient purchasing options and a single solution for laboratory operations management. Our products and services help our customers solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Visit www.thermofisher.com.