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Thermo Fisher Scientific (TMO) Introduces Innovative New Tools for Studying Live Cell Biology at the Eighth Annual Cambridge Healthtech Institute Meeting

1/12/2011 10:57:55 AM

PITTSBURGH, Pa. (Jan. 12, 2011) – Thermo Fisher Scientific Inc., the world leader in serving science, today introduced several new hardware and software enhancements to its flagship Thermo Scientific Arrayscan VTI HCS Reader, improving live-cell imaging and expanding visualization and open standards data management.

These enhancements are part of the Thermo Scientific High-Content 2.0 program and include the integration of the ZEISS Definite Focus hardware into the Arrayscan VTI HCS Reader’s live cell configuration. This change is designed to better support high-content analysis of living cells, such as the study of calcium signaling, pharmacokinetics, toxicity and GPCR’s . During such long term experiments the sample container often deforms due to thermal changes, however the Definite Focus hardware maintains the sample in sharp focus (for up to 20h) by the use of a long wavelength (infrared region) LED in combination with algorithms that adjust the instrument’s Z-drive, eliminating the need for repeated software autofocus and the photo-toxicity it may cause.

Definite Focus is integrated into the Arrayscan VTI HCS Reader and is available together with Thermo Fisher’s existing Arrayscan VTI Live Cell Module and Liquid Handling Module. This new hardware configuration coupled with our existing wide range of kinetic measurement tools, offers researchers unparalleled flexibility and ability to investigate myriad cellular processes in live cells.

New Thermo Scientific iView image mining software, also developed as part of Thermo Fisher’s High-Content 2.0 program, adds new visualization functionality to all the Thermo Scientific High content platforms. The iView software offers image centric analytics that allow easy visual quality control of experiments at the plate, well and cell level, while maintaining links to the quantitative data. Users can investigate cell phenotypes using “flow cytometry-like” scatter plots that allow visual correlation of cell phenotypes with the data. To complement the new Definite Focus enabled live cell configurations iView software can quickly create movies of live-cell kinetic experiments.

New Thermo Scientific openGateway software brings the benefits of all of our existing high-content informatics, image analysis tools and data mining software to all researchers who generate images and data whether from high-content platforms or microscopes. Developed using OME and web services standards, openGateway offers a rich XML standard format for data and images, together with a web service interface to allow them to be easily imported into the Thermo Scientific Store database. Once images and data are safely in the database they can be managed, accessed and analyzed. Users can then benefit from a single, open standard repository of images and data regardless of source.

The Definite Focus enabled Arrayscan VTI HCS Reader live cell configuration, the iView image mining software and openGateway interface will be demonstrated exclusively at booth #11 at the Cambridge Healthtech Institute High Content Analysis Meeting, Jan. 11-14, 2011, in San Francisco.

For more information on the entire Thermo Scientific range of products for high-content imaging, please visit Booth #11 at the Cambridge Healthtech Institute High Content Analysis Meeting, call 1-800-432-4091 or visit

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of more than $10 billion, we have approximately 35,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit

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