TetraPhase Pharmaceuticals Outlines Plans for Phase 3 Clinical Trial of Eravacycline IV/Oral in Complicated Urinary Tract Infections
10/1/2013 11:11:26 AM
WATERTOWN, Mass.--(BUSINESS WIRE)--Tetraphase Pharmaceuticals, Inc. (NASDAQ: TTPH), today announced the design of its planned Phase 3 IV/oral clinical trial of the Company’s lead antibiotic candidate eravacycline in the treatment of complicated urinary tract infections (cUTI). When initiated, this trial will be the second Phase 3 study of eravacycline underway. Tetraphase enrolled the first patient in a Phase 3 trial of eravacycline IV in complicated intra-abdominal infections (cIAI) in late August. “Eravacycline is the only late-stage antibiotic that is being developed to be dosed intravenously and orally, and that offers broad-spectrum activity, including coverage of carbapenem-resistant bacteria such as E. coli and Klebsiella spp.,” said Guy Macdonald, Tetraphase President and Chief Executive Officer. “As outlined in a recent report from the Centers for Disease Control and Prevention, multi-drug resistant infections, particularly Gram-negative infections, are a serious and rapidly growing threat to public health. With the start of this study, Tetraphase will be evaluating eravacycline in a Phase 3 program in each of two indications, cIAI and cUTI, taking full advantage of an FDA regulatory pathway designed to improve the availability of therapies addressing these serious infections.”
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