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Stroke Gene Discovered, Maastricht University Medical Center and University of Würzburg Study



9/22/2010 10:57:47 AM

ScienceDaily (Sep. 21, 2010) — A Dutch-German medical research team led by Harald Schmidt from Maastricht University, Netherlands, and Christoph Kleinschnitz, University of Würzburg, Germany, has discovered that an enzyme is responsible for the death of nerve cells after a stroke. The enzyme NOX4 produces hydrogen peroxide, a caustic molecule also used in bleaching agents. Inhibition of NOX4 by an experimental new drug in mice with stroke dramatically reduces brain damage and preserves brain functions, even when given hours after the stroke.

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