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Stemsynergy Announces Breakthrough in Treating Sarcomas With Its Novel Anti-Wnt Compound


8/9/2013 8:48:39 AM

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MIAMI--(BUSINESS WIRE)--Stemsynergy Therapeutics, Inc., today announced a breakthrough study for treating synovial sarcoma, an aggressive soft tissue cancer that predominantly affects teenagers and young adults. Stemsynergy is a privately held biopharmaceutical company that focuses on the discovery and development of small-molecule drugs targeting developmental pathways fundamental to cancer. Synovial sarcoma is a high-grade soft tissue cancer that is associated with a chromosomal rearrangement, meaning that chromosomes incorrectly switch positions. This results in production of a protein known as “oncogene SYT-SSX.” This protein promotes the uncontrolled cell proliferation that leads to cancer. The 10-year survival rate for individuals with synovial sarcoma is estimated to be as low as 10%. Previously, it was unknown how SYT-SSX caused cancer in people. In a recent study, published in Cancer Discovery, a group from Vanderbilt University Medical Center and Stemsynergy used mice to show that the SYT-SSX oncogene leads to the activation of a cell signaling process called the “Wnt pathway.” This work demonstrated that the Wnt signaling pathway is a master controller for the initiation and growth of synovial sarcomas, and that blocking this pathway can stop tumors from growing.

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