28th January 2013 -- Scientists at the Genome Institute of Singapore (GIS) headed a study which
culminated in the discovery of four processes by which gastric cancer is formed. With
gastric cancer being the second most common cause of cancer deaths worldwide
(almost 750,000 deaths annually) and also an Asian disease, this poses as an
extremely important find.
Using what is known as next-generation sequencing technologies, GIS scientists
were able to provide a comprehensive view of the gastric cancer genome,
characterizing micro- and macro-scale mutations. This led to the identification of four
distinct processes that cause mutations in gastric cancer. One of these was found to
have a targeted impact on genes and is potentially triggered by bacterial infection.
The other processes were found to have impact throughout the genome, and
included oxidative damage processes and the failure of DNA proof-reading
The discovery of the mutative actions of these processes provides essential clues to
the formation of gastric cancers, paving the way for diagnostics and targeted therapy.
The findings were published online in the December 2012 issue of Genome Biology.
The GIS is a research institute under the umbrella of the Agency for Science,
Technology and Research (A*STAR).
First author and GIS Principal Investigator Dr Niranjan Nagarajan said, “Cancers are
constantly evolving, and therefore understanding how they do so is important for
finding new treatments. Mutational processes in cancer had not previously been
shown to have a targeted impact on the genome and on genes. With this study, we
show evidence of this for the very first time. This is truly exciting since it moves us a
critical step towards understanding and finding a cure for gastric cancer.”
Co-author and GIS Principal Investigator Dr Patrick Tan said, “This is the first time
gastric cancers have been analyzed at the whole genome level. This work further
showcases the reputation of Singapore as a world-leader in gastric cancer research.”
“Our study demonstrates that sequencing gastric tumours not only allows the
identification of mutations in the human genome but also reveals microorganisms
and their pathogenic gene content,” added Dr Axel Hillmer, GIS Principal
GIS Executive Director, Prof Ng Huck Hui said, “"This is a very exciting study that
probed into the genomic signature of gastric cancers. Through the analysis of
somatic mutations occuring in gastric cancers, this team has identified several
interesting genes which have profound implications in cancers."
The study is a project under the Singapore Gastric Cancer Consortium (SGCC),
(a) local collaborators – Genome Institute of Singapore, Cancer Science
Institute of Singapore, National Cancer Centre Singapore, National University
Cancer Institute, National University Health System, Duke-NUS Graduate
Medical School Singapore, Nanyang Technological University, National
University of Singapore, Changi General Hospital, National University
Hospital, Singapore General Hospital, Tan Tock Seng Hospital; and
(b) international collaborators – Asia-Pacific Group on Gastric Cancer, Clinical
Therapeutics Research Group, Gastrome Project, International Cancer
The research findings described in the press release can be found in the 13
December 2012 advance online issue of Genome Biology under the title “Whole-
genome reconstruction and mutational signatures in gastric cancer”.
, Denis Bertrand1*
, Axel M Hillmer
, Zhi Jiang Zang3,4*
, Pierre-Étienne Jacques1
, Audrey SM Teo2
, Ioana Cutcutache6
, Wah Heng Lee1
, Yee Yen Sia2
, Song Gao7
, Pramila N Ariyaratne1
, Xing Yi Woo1
, Lavanya Veeravali
, Choon Kiat Ong9
, Niantao Deng10
, Kartiki V
, Chiea Chuen Khor
, Martin L Hibberd12,4
, Atif Shahab8
, Jaideepraj Rao13
, Mengchu Wu14
, Ming Teh15
, Feng Zhu19
, Sze Yung Chin15
, Brendan Pang14,15
, Guillaume Bourque17,18
, Richie Soong14,15
, Wing-Kin Sung1
, Bin Tean Teh9
, Steven Rozen6
, Xiaoan Ruan2
, Khay Guan Yeoh19
, Patrick BO Tan10,12,14#
, Yijun Ruan2,20#
1. Computational and Systems Biology, Genome Institute of Singapore, Singapore
2. Genome Technology and Biology, Genome Institute of Singapore, Singapore
3. Cellular and Molecular Research, National Cancer Centre, Singapore 169610,
4. Cancer and Stem Cell Biology Program, Duke–National University of Singapore
(NUS) Graduate Medical School, Singapore 169857, Singapore.
5. Department of Epidemiology and Public Health, Yong Loo Lin School of
Medicine, National University of Singapore, Singapore 119074, Singapore.
6. Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,
Singapore 169857, Singapore.
7. NUS Graduate School of Integrative Sciences and Engineering, Centre for Life
Sciences, Singapore 117456, Singapore
8. Research Computing, Genome Institute of Singapore, Singapore 138672,
9. NCCS-VARI Translational Research Laboratory, National Cancer Centre,
Singapore 169610, Singapore.
10. Genomic Oncology, Duke-NUS Graduate Medical School, Singapore 169857,
11. National Insitute of Biomedical Genomics, 2nd
Floor Netaji Subash Sanatorium,
Kalyani 741251 West Bengal, India.
12. Infectious Diseases, Genome Institute of Singapore, Singapore 138672,
13. Department of Surgery, Tan Tock Seng Hospital, Singapore 308433,
14. Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore 119074, Singapore.
15. Department of Pathology, National University Health System, National
University of Singapore, Singapore 119074, Singapore.
16. Department of Surgery, National University Health System, National University
of Singapore, Singapore 119074, Singapore.
17. Department of Human Genetics, McGill University, Montréal H3A 1B, Canada.
18. McGill University and Genome Quebec Innovation Center, Montréal H3A 1A4,
19. Department of Medicine, National University Health System, National University
of Singapore, Singapore 119074, Singapore.
20. Department of Biochemistry, National University of Singapore, Singapore
* These authors contributed equally to this work.
# Corresponding Authors: Niranjan Nagarajan (firstname.lastname@example.org),
Patrick Tan (email@example.com).
Genome Institute of Singapore
Office of Corporate Communications
Tel: (65) 6808 8013
About the Genome Institute of Singapore (GIS)
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science,
Technology and Research (A*STAR). It has a global vision that seeks to use
genomic sciences to improve public health and public prosperity. Established in 2001
as a centre for genomic discovery, the GIS will pursue the integration of technology,
genetics and biology towards the goal of individualized medicine.
The key research areas at the GIS include Systems Biology, Stem Cell &
Developmental Biology, Cancer Biology & Pharmacology, Human Genetics,
Infectious Diseases, Genomic Technologies, and Computational & Mathematical
Biology. The genomics infrastructure at the GIS is utilized to train new scientific
talent, to function as a bridge for academic and industrial research, and to explore
scientific questions of high impact.
About the Agency for Science, Technology and Research (A*STAR)
The Agency for Science, Technology and Research (A*STAR) is Singapore's lead
public sector agency that fosters world-class scientific research and talent to drive
economic growth and transform Singapore into a vibrant knowledge-based and
innovation driven economy.
In line with its mission-oriented mandate, A*STAR spearheads research and
development in fields that are essential to growing Singapore’s manufacturing sector
and catalysing new growth industries. A*STAR supports these economic clusters by
providing intellectual, human and industrial capital to its partners in industry.
A*STAR oversees 20 biomedical sciences and physical sciences and engineering
research entities, located in Biopolis and Fusionopolis as well as their vicinity. These
two R&D hubs house a bustling and diverse community of local and international
research scientists and engineers from A*STAR’s research entities as well as a
growing number of corporate laboratories.