Sigma(R) Life Science Introduces CompoZr(R) Targeted Integration Kit for Controlled Transgene Expression in Human Cell Lines
ST. LOUIS, April 20 /PRNewswire-FirstCall/ -- Sigma(R) Life Science, the innovative biological products and services brand of Sigma-Aldrich(R) , today announced an extension to its award-winning CompoZr(R) product offering with the global release of the CompoZr Targeted Integration Kit, AAVS1 (www.sigma.com/aavs1). This kit provides a powerful method for the controlled transgene integration and expression of any gene in any human cell line using Sigma-Aldrich's proprietary CompoZr Zinc Finger Nuclease (ZFN) technology.
"Our new Targeted Integration Kit provides a valuable tool for scientists working with all types of human cells, including stem cells," said Patrick Sullivan, vice president of Research and Development for Sigma-Aldrich's Research Biotech business unit. "Similar to what the Rosa26 locus has done for transgenic research in mice, we believe the AAVS1 locus will provide a 'safe harbor' site from which to study gene function and expression. The kit, using Zinc Finger Nuclease technology, enables researchers to insert any gene construct into the human genome. This new kit is an exciting addition to our offering of CompoZr products, and will facilitate the construction of isogenic cells with permanent, stable gene expression."
More information on Sigma-Aldrich's CompoZr ZFN technology platform can be accessed by visiting www.compozrzfn.com, part of the recently-launched 'Where Bio Begins' brand and website (www.wherebiobegins.com). 'Where Bio Begins' is a leading digital destination where the biological research community can directly access the deep biological knowledge they require for their research, while driving awareness of Sigma-Aldrich's strengths in providing products and technologies that facilitate scientists' understanding of how diseases develop and how molecules function.
About Sigma Life Science: Sigma Life Science is a Sigma-Aldrich brand that represents Sigma's leadership in innovative biological products and services for the global life science market and offers an array of biologically-rich products and reagents that researchers use in scientific investigation. Product areas include biomolecules, genomics and functional genomics, cells and cell-based assays, transgenics, protein assays, stem cell research, epigenetics and custom services/oligonucleotides. Sigma Life Science also provides an extensive range critical bioessentials like biochemicals, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, amino acids and their derivatives, and cell culture media.
CompoZr, Sigma-Aldrich and Sigma are trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.
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