BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Sigma-Tau Pharmaceuticals Cysteamine Eye Drop NDA Accepted for Filing


5/17/2010 10:59:01 AM

GAITHERSBURG, Md., May 17 /PRNewswire/ -- Sigma-Tau Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has accepted the filing of the company's new drug application (NDA) for its cysteamine hydrochloride ophthalmic solution, an investigational therapy for the treatment of corneal cystine crystals in patients with cystinosis. The FDA also granted the NDA Priority Review status, a designation given to drugs that may provide major advances or a treatment where no adequate therapy exists.

Cystinosis is a rare disease affecting as few as 300 people in the U.S. The company has been granted orphan drug designation for this product and previously received a grant from the FDA's Orphan Drug Products Division to help fund the treatment research. If approved, this medicine will be the first FDA approved treatment for corneal cystine crystal accumulation, which can lead to changes in visual acuity and photophobia (i.e., sensitivity to light).

"Acceptance of the NDA marks an important milestone for both Sigma-Tau and the cystinosis community," said Gregg Lapointe, Chief Executive Officer of Sigma-Tau Pharmaceuticals. "If approved, this treatment has the potential to offer important benefits for patientsmany of whom are childrenwhose care has been limited due to a lack of therapeutic options and access."

The NDA includes data from clinical trials conducted at the National Institutes of Health (NIH) National Eye Institute. Results of the studies indicate that administration of cysteamine hydrochloride eye drops may be effective in the prevention and treatment of corneal cystine crystals.

"Cystinosis is a devastating disease that too often robs children of normal vision," said Christy Greeley, President and Executive Director of the Cystinosis Research Network, Inc. "We are excited about the prospect of a new, accessible treatment option for our kids."

About Cystinosis

Cystinosis is a rare, genetic lysosomal storage disease characterized by the abnormal accumulation of the amino acid cystine. It is estimated that 2,000 individuals worldwide have cystinosis. Primarily affecting children, cystine crystals accumulate in the kidneys, liver, muscles, pancreas, brain, white blood cells and eyes. While treatment for reducing cystine accumulation in the body exists, there is currently no FDA approved treatment for corneal cystine crystal accumulation, which can lead to changes in visual acuity and photophobia (i.e., sensitivity to light).

About Sigma-Tau Pharmaceuticals, Inc.

Sigma-Tau Pharmaceuticals, Inc. is a U.S. based, wholly owned subsidiary of the sigma-tau Group, and is dedicated solely to the global development and commercialization of medicines for patients with rare diseases. Sigma-Tau Pharmaceuticals, Inc. is based in Gaithersburg, Maryland.

Since 1989, the company's products have been focused on rare diseases, kidney disease, and cancer. With more than 6,000 identified rare diseases that affect approximately 25 million patients in the United States, Sigma-Tau places its considerable scientific resources behind the development and commercialization of compounds that benefit the few. The company has substantial development programs focused on transplant, cancer, inherited genetic disorders, malaria, and other areas of unmet medical need.

For more information about the company, visit www.sigmatau.com.

About sigma-tau Group

sigma-tau Group is a leading, international, pharmaceutical group with a wholly Italian-owned capital that invests in the research, development and marketing of innovative and effective treatments to improve patient well-being and quality of life. sigma-tau has its headquarters in Pomezia (Rome, Italy), and subsidiaries in France, Switzerland, Belgium, the Netherlands, Portugal, Germany, the UK, USA and India, as well as in Spain and Sudan where the Group operates two production facilities. It has over 2300 employees and an extensive network of licensees worldwide. sigma-tau was founded in Italy in 1957 and achieved a global turnover of 613 million euros ($909 million) in 2008. sigma-tau SpA consistently invests approximately 16% of its annual turnover in R&D. sigma-tau's R&D staff of approximately 400 people is currently running 46 R&D projects. A total of 13 NCEs and 12 known molecular entities in 33 different indications are at various stages of development. Among them, several are aimed at rare diseases. Therapeutic areas in which the company's research and development are focused include metabolism, neurology, cardiovascular, oncology and immunology. sigma-tau website: www.sigma-tau.it.

Company Contact:

Marc Tewey

Sigma-Tau Pharmaceuticals, Inc

VP Commercial Operations

9841 Washingtonian Blvd, Suite 500

Gaithersburg, MD 20878

301-948-1041



SOURCE Sigma-Tau Pharmaceuticals



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES