Sera Lab Launches Extensive Microsome and S9 Fraction Range for Drug Metabolism Studies

Haywards Heath, UK – 7th December 2010. Sera Laboratories International Ltd (Sera Lab), the serum specialist, has launched a comprehensive range of liver microsome products from over 12 species, including mouse, rabbit, monkey and chicken. Researchers can select from pure microsomes or S9 fractions, and animal liver cytosol is also available. In order to facilitate requirements recommended by REACH, Sera Lab is also able to supply bespoke microsome products from other species or strains, as required. Each product is accompanied by a Certificate of Analysis.

Microsomes are a valuable tool for investigating drugs metabolism (enzyme inhibition, clearance and metabolite identification), as well as for examining in vitro drug-drug interactions. They are produced by mechanically homogenising cells such that the endoplasmic reticulum is fragmented, the fractions of which reform into microsomes, which are subsequently collected from the cell remnants via differential centrifugation. During this process, the numerous different phase I cytochrome P450 enzymes (CYPs) are concentrated within the microsomes. The S9 fraction contains microscomes as well as cytosolic phase II metabolism-related enzymes.

With this extensive portfolio of microsomes and S9 fractions, as well as the capability to provide bespoke products, Sera Lab offers researchers the opportunity to match the species, strain and enzyme activity requirements for successful drug metabolism studies.

For further information, please email sales@seralab.co.uk or visit www.seralab.co.uk

About Sera Lab

Founded in 1998, Sera Laboratories International Ltd (Sera Lab), the serum specialist, is a leading supplier of core biomedical products and services for clinical and research diagnostics, drug discovery and development, and life science research. With headquarters and storage in the UK and a cell culture research facility in France, Sera Lab offers the most complete range of animal-based research products in Europe from a wide variety of origins. Sera Lab supplies laboratories in over 30 countries throughout the world, either directly or through distributors. A new UK production facility at a sister company has further expanded the company’s capabilities and capacity.

Sera Lab’s quality products provide key advantages in a range of research disciplines including cell biology, genomics, proteomics, virology, immunology, drug discovery and toxicology. They are important tools for defining the pharmacokinetic and pharmacodynamic properties of newly discovered compounds and their effects on disease processes. With over 30 years experience, the company’s management and R&D teams are continually developing new products that allow researchers to push the boundaries of research. Through an exclusive association with UK-based Antibody Production Services Limited (APS), Sera Lab offers a Custom Antibody Service to provide polyclonal and monoclonal antibodies from a wide variety of species.

Sera Lab’s Contract Manufacture Service can supply any serum, plasma or media product to suit a customer’s individual requirements. Other contract services include filtration, media production and freeze-drying.