January 13, 2011 -- Scientists at the Center for Integrated Protein Science Munich (CIPSM), based at Ludwig¬Maximilians University Munich (LMU), Germany, have taken advantage of the 3D scanning capabilities of the premium Quad4 Monochromators™-based Infinite M1000 microplate reader to investigate nanobodies.
Professor Heinrich Leonhardt, Professor of Molecular Human Biology at LMU, explained: “We have been able to use the 3D scanning capability of the M1000 to study nanobody¬induced changes of the spectral properties of GFP in living cells. The results are really beautiful.” Dr Carina Frauer, a scientist at LMU, continued: “We co-expressed GFP in cells with specific nanobodies which modulate the spectral properties of GFP. 3D scanning shows excitation and emission on the same plot, very nicely illustrating the shift in GFP fluorescence excitation and emission wavelengths induced by nanobody binding.”
Professor Leonhardt concluded: “The instrument is flexible, easy to use and very fast, which has increased the speed of the assay. The software is simple to understand and, if we need any additional advice, Tecan is happy to help. We focus on developments in technology and the application of new methods, and the Infinite M1000’s versatility really helps in this.”
For more information on Tecan’s Infinite M1000 visit http://www.tecan.com/infinitem1000
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Tecan (www.tecan.com) is a leading global provider of laboratory instruments and solutions in biopharmaceuticals, forensics, and clinical diagnostics. The company specializes in the development, production and distribution of instruments and automated workflow solutions for laboratories in the life sciences sector. As an original equipment manufacturer, Tecan is also a leader in developing and manufacturing OEM instruments and components that are then distributed by partner companies. Founded in Switzerland in 1980, the company has manufacturing, research and development sites in both Europe and North America and maintains a sales and service network in 52 countries. In 2009, Tecan generated sales of CHF 392 million (USD 361.2 million; EUR 259.6 million). Registered shares of Tecan Group are traded on the SIX Swiss Exchange (TK: TECN/Reuters: TECZn.S/ ISIN CH0012100191).
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