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Scarab Genomics: Clean Genome(R) E. coli MDS(TM) 42 Strains for Optimal Biotherapeutic Production


11/10/2009 9:42:25 AM

MADISON, Wis.--(BUSINESS WIRE)--Scarab Genomics has made a series of planned, precise deletions to the E. coli K-12 genome, reducing the genome by more than 15%. The multiple-deletion series (MDS™) strains eliminate non-essential genes, cryptic virulence genes, and sequences of recombinogenic and mobile insertion sequence (IS) DNA, while preserving robust growth in rich and minimal media. Removal of IS elements, which are a prevalent but frequently overlooked problem, improves clone stability. Prophage, which can be stress activated and cause premature lysis and failed fermentation runs, as seen with BL21(DE3), have been removed from these strains. Genome reduction optimizes Clean Genome E. coli for recombinant DNA and protein production, providing superior genomic and plasmid stability, increased cloning success with “unclonable” genes, and lower background for downstream processing, … making them the strains of choice for manufacturing biotherapeutics.

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