SEOUL, South Korea, Nov. 16, 2011 /PRNewswire/ -- Research study on developing the advanced homing effect of stem cells has been published.
Research team at RNL BIO led by Dr. Jeong Chan Ra has conducted a study on how chemokines and other growth factors, which are cellular signaling molecules, fat derived stem cell activity. The team identified that TNF-alpha (Tumor Necrosis Factor-alpha): a cytokine that regulates the response to the immune system was used to stimulate stem cells, increased stem cell activity significantly. The findings of this study were published by Korean Society for Biochemistry and Molecular Biology's a journal in English, Experimental and Molecular Medicine. This revolutionary technology in stem cells is patent pending.
As the ability of stem cells migrating to damaged areas is well known, stem cells also have the ability to detect proteins that are secreted from the damaged tissue. Stem cells are chemo-tactic to detect movement (as amoeba, white blood cells attracted to chemicals and the movement around it). Research teams compared stem cell activity in the environment of chemokines and growth factors. Both factors induce the migration of stem cells, however, growth hormone appeared to be more effective. In particular, PDGF-AB, TGF-beta1, TNF-alpha were exposed to growth hormones to observe the active migration of stem cells.
Interestingly, the factors that enhance the migration of stem cells exhibited improvement when used to stimulate stem cells. Among these factors TNF-alpha showed the best response from stem cells. It was confirmed that stem cells' homing effect improved up to 4.4 times when stimulated by chemo-tactic chemokines and growth hormones.
Dr. Ra, president of RNL Stem Cell Technology Institute, said, "Stem cell treatment is a simple procedure that can treat incurable diseases without surgery. As the enhanced stem cells' homing effect was discovered through this study, it is expected to increase the therapeutic effect and efficiency in stem cell treatment."
SOURCE RNL BIO