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RIFM Adopts Bluescreen HC™ for Early Genetic Toxicology Screening of Fragrance Materials



6/19/2013 10:01:25 AM

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June 19, 2013 -- As part of its continuing mission to ensure the safety of fragrance ingredients, the Research Institute for Fragrance Materials, Inc. (RIFM) has incorporated early screening with BlueScreen™ into its genotoxicity profiling regime. RIFM is a non-profit research institute whose purpose is to gather and analyse scientific data, engage in testing and evaluation, distribute information, cooperate with official agencies and to encourage uniform safety standards related to the use of fragrance ingredients. To meet these goals, RIFM takes advantage of recent innovations in risk assessment methodology. The use of BlueScreen™ HC provides accurate, sensitive results that are efficiently integrated into RIFM’s testing cascade and enable more efficient fragrance material evaluation.

BlueScreen™ HC is a highly specific, sensitive human cell based assay used to screen chemicals for their potential to cause damage to DNA: a property known as genotoxicity. Based on technology already used in the pharmaceutical industry, BlueScreen HC is used to provide a rapid assessment of potential hazard across diverse chemical collections in the assessment of new chemicals that are candidates for product development.

The assay evaluates the up-regulation of a key gene’s, GADD45a, response to a chemical that causes damage to, or interferes with, DNA. It measures the luminescence generated from the enzyme Gaussia Luciferase from the marine crustacean Gaussia princeps.

The gene is incorporated into the human TK6 cells used in the assay and linked to GADD45a production.

RIFM and the originators of BlueScreen HC, Gentronix Limited are working closely on the assessment of fragrance materials for use in a wide range of consumer products.

“We found BlueScreen™ HC to be a very useful tool in our fragrance material evaluation process” said RIFM President, Dr. David Wilcox.

Gentronix Commercial Director, Dr. Steve Beasley said: “We have been impressed with the scientific rigor that RIFM brings to the safety evaluation of fragrance materials and their assessment of new technologies such as BlueScreen HC. We look forward to continuing this important collaboration.”

About RIFM

RIFM is the international scientific authority for the safe use of fragrance materials. RIFM generates, evaluates and distributes scientific data on the safety assessment of fragrance raw materials found in personal and household care products. Through extensive research, testing and constant monitoring of all scientific literature and technology available, RIFM maintains its Database as the most comprehensive source worldwide of physical-chemical, toxicological and eco-toxicological data associated with known fragrance and flavour materials. All of RIFM’s scientific findings are evaluated by an independent expert panel—an international group of dermatologists, pathologists, toxicologists, reproduction, respiratory and environmental scientists. The expert panel evaluates the safety of fragrance ingredients under conditions of intended use and publishes its results in peer-reviewed scientific journals. The decisions of the expert panel regarding restrictions of use are also published as IFRA Standards. For more information about RIFM and its activities, visit www.rifm.org or e-mail rifm@rifm.org.

About Gentronix

Gentronix provides services and solutions to help organisations optimise the development of drugs and other chemicals, by reducing attrition due to toxicity thus ensuring safer products across a wide range of chemistry driven industries. We provide a range of reagent-based products as well as contract services for genotoxicity using our patented human cell GADD45a reporter GreenScreen HC® and BlueScreen HC™ assays and related assays including Micronucleus, Ames MPF™ and Comet. For further information please visit www.gentronix.co.uk

For further information, please contact: Steve Beasley, Commercial Director, Gentronix Limited, CTF Building, 46 Grafton Street, Manchester, M13 9NT UK.

T +44 (0)161 603 7676 E steve.beasley@gentronix.co.uk, Website: www.gentronix.co.uk

For further press information, please contact: Catherine Butcher, or Nicola Aldren, Barrett Dixon Bell, Craig Court, 25 Hale Road, Altrincham, Cheshire WA14 2EY UK.

Tel: +44 (0)161 925 4700 Fax: +44 (0)161 925 4701

Email: catherine@bdb.co.uk, nicola@bdb.co.uk

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