Regeneron is developing VEGF-Trap as a fully humanized VEGF-receptor fusion protein and a potent angiogenesis inhibitor, created by the company’s proprietary cytokine trap technology. VEGF-Trap may be considered as a next-generation VEGF blocker to Genentech’s Avastin and Lucentis, lead anti-angiogenesis drugs that have achieved blockbuster status since their commercial launch. In terms of the mechanism of action, VEGF-Trap acts similarly to Avastin in blocking the activity of VEGF. Due to its unique design, VEGF- Trap may have a superior pharmacokinetic profile while maintaining a high binding affinity that may potentially translate into better efficacy in comparison with Avastin.
We think investors should take a look at Regeneron, given the steady progress over the last few years on its cytokine trap technology platform. Currently, it is estimated 2007 U.S. Avastin sales will be $2.3 billion and Lucentis sales more than $800 million. Even though VEGF-Trap could come much later to market as a VEGF blocker in oncology and AMD, there is room for Regeneron to take market share if competitive features are demonstrated. Regeneron’s shares have been weak lately, but we think it’s an opportunity for investors. To learn more about Regeneron, take at look at last month’s and our current issue of Wong’s BioTech Stock Report.
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