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Rare Mutations Increase Risk of Late-Onset Alzheimer's Disease, Massachusetts General Hospital Study


9/25/2013 6:45:53 AM

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Massachusetts General Hospital (MGH) researchers have identified and validated two rare gene mutations that appear to cause the common form of Alzheimer's disease (AD) that strikes after the age of 60. The two mutations occur in a gene called ADAM10 -- coding for an enzyme involved in processing the amyloid precursor protein -- which now becomes the second pathologically-confirmed gene for late-onset AD and the fifth AD gene overall.

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