Protherics PLC Announces Major Interest in Shares

London, UK; Brentwood, TN, US: 23 November 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that on 22 November 2007, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from HBOS plc. Details of the interest notified are as follows: