BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Proacta Inc. and Yakult Honsha Announce Expansion of Their Collaborative Research, Development and Commercialization Agreement


8/3/2011 10:56:48 AM

SAN DIEGO, Aug. 3, 2011 /PRNewswire/ -- Proacta Incorporated and Yakult Honsha Co., Ltd. (Tokyo: 2267) today announced the expansion of their Collaborative Research, Development and Commercialization Agreement to also include Proacta's PR610 compound, a hypoxia-activated pro-drug for the treatment of cancer. Based on compelling pre-clinical data on PR610, the parties agreed to expand their existing collaboration to include PR610. The initial agreement, signed in February 2011, for Proacta's hypoxia-activated pro-drug, PR509, granted Yakult research, development and commercialization rights to PR509 in Japan.

(Logo: http://photos.prnewswire.com/prnh/20110803/LA45514LOGO)

(Logo: http://photos.prnewswire.com/prnh/20110222/LA50556LOGO-b)

"Based on recent pre-clinical study results, we believe that PR610 could perform very well in the clinic," said John C. Gutheil, MD, Proacta's CEO. "We have developed a strong relationship with Yakult in the short time that we have been working together. We are delighted that Yakult is interested in PR610 and that they share our optimism regarding the potential of this molecule."

Mr. Shigeyoshi Sakamoto, Head, Pharmaceutical Division/ Managing Executive Officer, Member of the Board of Yakult, said, "We are pleased to have the opportunity to expand our collaborative research, development, and commercialization agreement with Proacta to include PR610. This molecule has shown unique promise and provides Yakult with an option on two promising molecules within Proacta's hypoxia-activated irreversible multi-kinase inhibitors portfolio for the treatment of cancer. We look forward to the continued progress and advancement of the program so that we can more quickly bring promising new treatments to patients suffering from cancer."

About PR509 and PR610

PR509 and PR610 are Proacta's proprietary hypoxia-activated irreversible multi-kinase inhibitors discovered at the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. Reversible multi-kinase inhibitors (MKI) are currently in use for the treatment of several types of cancer. However, resistance often develops to reversible MKI's. In addition, reversible MKI's have side effects that limit their use at higher doses. Both PR509 and PR610 utilize an irreversible MKI that is activated only in areas of severe hypoxia, a characteristic of most solid tumors. Localized release of the irreversible MKI leads to higher concentrations in the tumor relative to normal tissues, which should result in improved efficacy and fewer side effects. In addition, irreversible MKI inhibitors are not effected by some of the resistance mechanisms that limit use of reversible MKI inhibitors.

Clinical Development Status

PR509 and PR610 are currently targeted for development in non-small cell lung cancer resistant to reversible tyrosine kinase inhibitors such as erlotinib and /or gefitinib, where an effective treatment has yet to be established. In addition to NSCLC, Proacta expects to evaluate the molecules in other cancers such as gastric, breast, and pancreatic that are currently treated with first-generation reversible tyrosine kinase inhibitors.

About Proacta Incorporated

Proacta is a San Diego based biotechnology company dedicated to the development and commercialization of hypoxia-activated oncology drugs. Proacta is currently conducting a phase II study of PR104, a hypoxia activated alkylator, in patients with relapsed or refractory leukemia. In addition, Proacta has a pipeline of hypoxia-activated prodrugs for the treatment of cancer that are licensed from the University of Auckland in New Zealand. For more information on Proacta, visit the Proacta web site at www.proacta.com.

About Yakult

Yakult is a leading Japanese company focused on the development and marketing of pharmaceuticals, foods, beverages, and cosmetics. With respect to its pharmaceutical business, Yakult has an emerging presence in oncology. For more information on Yakult, visit: http://www.yakult.co.jp/english/index.html or view the following company profile:

http://www.yakult.co.jp/english/pdf/profile2010-2011.pdf

SOURCE Proacta Incorporated; Yakult Honsha Co., Ltd.



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES