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Possible AIDS Treatment Shows Promise in Monkeys, Yerkes National Primate Research Center, Dana-Farber Cancer Institute, Harvard Medical School And University of Pennsylvania Study



12/11/2008 7:18:50 AM

ScienceDaily (Dec. 11, 2008) — By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV). The therapeutic strategy worked by boosting the function of anti-viral killer cells (CD8 T cells) and improving antibody response to the virus.

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