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Poor Kids Grow Up More Susceptible to Catching Colds, Carnegie Mellon University Researchers Find


11/5/2013 3:21:48 PM

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Children of Lower Socioeconomic Status Grow Up More Susceptible to Catching Colds

November 6, 2013 -- PITTSBURGH — Researchers at Carnegie Mellon University have found an association between lower socioeconomic status during childhood and adolescence and the length of telomeres, protective cap-like protein complexes at the end of chromosomes that ultimately affect the susceptibility to colds in middle-aged adults.

Published in Brain, Behavior and Immunity, the study showed that children and teens with parents of lower socioeconomic status have shorter telomeres as adults. Telomere length is a biomarker of aging with telomeres shortening with age. As a cell's telomeres shorten, it loses its ability to function normally and eventually dies. Having shorter telomeres is connected to the early onset of illnesses such as cardiovascular disease and cancer, with mortality in older adults and, as CMU's Sheldon Cohen first discovered, predicts susceptibility to acute infectious disease in young to midlife adults. This new research now links low childhood socioeconomic status to shorter telomeres and an increased susceptibility to the common cold.

"This provides valuable insight into how our childhood environments can influence our adult health," said Cohen, the Robert E. Doherty Professor of Psychology in CMU's Dietrich College of Humanities and Social Sciences.

In the study, Cohen and his team measured the telomere lengths of white blood cells from 152 healthy volunteers between the ages of 18 and 55. To gauge childhood and current socioeconomic status, the participants reported whether they currently own their home and whether their parents owned the family home when they were between the ages of 1 and 18. They were then exposed to a rhinovirus, which causes a common cold, and quarantined for five days to see if they actually developed an upper respiratory infection.

The results showed that participants with lower childhood socioeconomic status — indicated by fewer years that their parents were homeowners — had shorter than average telomere length. Telomere length decreased by 5 percent for each year the participants' parents did not own a home. The researchers also found that parental homeownership in both early childhood and adolescence were both associated with adult telomere length. The participants with lower childhood socioeconomic status were also more likely to become infected by the cold virus. Specifically, for each year their parents did not own a home during their childhood years up to age 18, the participants' odds of developing a cold increased by 9 percent.

"We have found initial evidence for a biological explanation of the importance of childhood experiences on adult health," Cohen said. "The association we found in young and midlife adults suggests why those raised by parents of relatively low socioeconomic status may be at increased risk for disease throughout adulthood."

In addition to Cohen, the research team included CMU's Denise Janicki-Deverts; the University of Virginia Health Science Center's Ronald B. Turner; the University of Pittsburgh's Anna L. Marsland; Children's Hospital of Pittsburgh's Margaretha L. Casselbrant, Ha-Sheng Li-Korotky and William J. Doyle; and the University of California San Francisco's Elissa S. Epel. The National Institute of Allergy and Infectious Diseases and the National Center for Complementary and Alternative Medicine funded this research.

For more information, visit http://www.psy.cmu.edu/~scohen/.

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