Pfizer Inc.'s Zyvox and Antidepressants May Be Fatal Combination

Pfizer Inc. (PFE)’s Zyvox antibiotic can cause potentially fatal central nervous system reactions in patients who also take antidepressants that increase levels of the brain chemical serotonin, U.S. regulators said. Pfizer’s Zoloft and Pristiq, Eli Lilly & Co. (LLY)’s Cymbalta and GlaxoSmithKline Plc (GSK)’s Paxil and Wellbutrin are among 29 psychiatric drugs that patients may need to stop taking temporarily when they require treatment with Zyvox, the Food and Drug Administration said today in a drug safety communication.