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PeroXeal(TM) - New Packaging for a Traditional BASF Product


10/25/2011 10:13:15 AM

October 25, 2011 -- BASF has developed a packaging system which sets new quality standards: In the future PeroXeal™ will protect the pharmaceutical excipient Kollidon ® , based on PVP (polyvinylpyrrolidone), even better against contact with oxygen and subsequent o xidation. This makes it possible to significantly reduce the peroxide level of Kollidon ® , making the excipient suitable for use in oxygen-sensitive formulations as well. Under the trade name Kollidon®, PVP is used in tablets as a binder and as disintegrant.

"With PeroXeal™ BASF is setting new standards for excipients in terms of formula stability and purity and can thus help its customers in the pharmaceuticals industry achieve higher levels of patient safety," says Dr. Boris Jenniches, head of Global Business Management PVP at BASF. "With our new packaging concept we can significantly reduce peroxide values to a level comparable with that of naturally-based raw materials. This makes Kollidon® a viable alternative to naturally-based raw materials". Generally, Kollidon® as synthetic polymer shows less variability in processing compared to its natural counterparts. Further advantages of PeroXeal™: The shelf life of the excipient is extended and by-products in the formulation are reduced.

Gradual conversion to PeroXeal ™

The multi-layered and heat-sealed plastic film of the PeroXeal ™ packaging system , used as inner packaging material, is completely aluminum-free and thus more environmentally friendly. The transparent PeroXeal ™ film makes the NIR (Near-Infrared Spectroscopy) test possible: The packaging can remain sealed until the product is used, keeping the excipient Kollidon ® stable.

PeroXeal™ doesn't mean any additional cost for the customer. The new packaging concept has already been introduced for the most important Kollidon® products at the Ludwigshafen and Minden sites. BASF will offer all grades of the Kollidon® line starting 2013 with its new technology.

PVP – an all-around talent with tradition

PVP has a very long success story: More than 70 years ago the BASF chemist Walter Reppe, working in a laboratory in Ludwigshafen, used acetylene and pyrrolidone to produce a new monomer, vinylpyrrolidone, which itself can be turned into the polymer polyvinylpyrrolidone. PVP is water soluble, but is also capable of absorbing large quantities of water; it is not a skin irritant, poses no health risks, is temperature resistant, pH-stable, non-ionic and colorless. Its widely varied properties make PVP ideal for a broad spectrum of applications. PVP turns tablets into a true high-tech product: As a binder it holds together the individual active ingredients in the tablet to form a homogenous whole, while as disintegrant it ensures that tablets dissolve in liquids and quickly release their active ingredients. The polyvinylpyrrolidones BASF manufactures are used for the most part in the pharmaceuticals sector.

You can download a press photo at www.basf.com/pressphoto-database under the keyword "BASF SE", search term "Peroxeal".

About BASF’s Pharma Ingredients & Services

BASF produces and markets a broad range of active ingredients and excipients, as well as exclusive synthesis services for the pharmaceutical industry. These products are made using the latest technologies, to the highest quality standards and in compliance with cGMP guidelines. Further information can be found at www.pharmaingredients.basf.com .

About BASF

BASF is the world’s leading chemical company: The Chemical Company. Its portfolio ranges from chemicals, plastics, performance products, and agricultural products to oil and gas. As a reliable partner BASF creates chemistry to help its customers in virtually all industries to be more successful. With its high-value products and intelligent solutions, BASF plays an important role in finding answers to global challenges such as climate protection, energy efficiency, nutrition and mobility. BASF posted sales of more than €63.9 billion in 2010 and had approximately 109,000employees as of the end of the year. Further information on BASF is available on the Internet at www.basf.com or in the Social Media Newsroom at newsroom.basf.com


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