Penumbra To Highlight Importance Of Stroke Treatment At Upcoming Patient Awareness Events

Stroke Patients Treated with Penumbra System® to Ring Opening Bell at NYSE, Marking One-Year IPO Anniversary

ALAMEDA, Calif. – September 27, 2016 – Penumbra, Inc. (NYSE:PEN), a global interventional therapies company, today announced a series of events in New York City aimed to raise awareness for stroke treatment, coinciding with the one-year anniversary of the company’s initial public offering. Stroke remains an undertreated disease, and the events aim to bring attention to the importance of getting patients to hospitals in time for endovascular treatment.

Together with stroke patients who represent over 20 U.S. states and were treated with the Penumbra System®, the company will participate in the following events:

• Stroke Awareness Day at Yankee Stadium – Sept. 28: Penumbra will sponsor a stroke treatment awareness event organized by The Joe Niekro Foundation™ during the Boston Red Sox vs. New York Yankees game at Yankee Stadium. The Joe Niekro Foundation™ is committed to supporting stroke patients and families, research, treatment and awareness. The event will pay tribute to and honor stroke patients with the goal of highlighting the importance of timely treatment. Stroke patients will be recognized on the field before the game and a public service announcement will be shared as part of the event.

• NYSE Bell Ringing – Sept. 29: To commemorate the one-year anniversary of Penumbra’s initial public offering, the company and the New York Stock Exchange are inviting stroke patients to ring the opening bell.

• A Cerebral Affair – Sept. 29: Penumbra is a platinum sponsor of the “A Cerebral Affair” fundraising gala, hosted by The Lisa Colagrossi Foundation and The Joe Niekro Foundation™. The event aims to benefit awareness and research for brain aneurysms, a potential cause for hemorrhagic stroke.

“Penumbra is honored to bring patients together from all over the country to draw attention to the critical issue that treatable stroke patients need to get to the right hospitals for access to endovascular stroke treatment,” said Adam Elsesser, chairman and chief executive officer of Penumbra. “When these patients get to the right hospital, the benefit can be profound and life changing for the patients and their families.”

Important Facts about Stroke and Stroke Treatment

• About every four minutes, one American dies from a stroke – a brain attack caused by a ruptured or blocked artery.

• Stroke is the fifth leading cause of death and a leading cause of disability in the U.S.

• Advances in stroke treatments – including endovascular treatment, which acts like a minimally invasive “vacuum” to remove the blood clot inside the blocked artery in the brain – are leading to better survival and quality of life.

• Only about 10 percent of patients receive endovascular treatment because others don’t arrive in time to the right stroke centers that offer the procedure.

• Several published studies, including the landmark MR CLEAN study in the New England Journal of Medicine, showed that endovascular treatment is a superior treatment option compared to the clot-busting drug tPA.

• By knowing the signs of stroke and acting F-A-S-T (Face drooping, Arm weakness, Speech difficulty and Time to call 911), stroke victims can get timely treatment and are twice as likely to survive.

About Penumbra

Penumbra, Inc., headquartered in Alameda, California, is a global interventional therapies company that designs, develops, manufactures and markets innovative medical devices. The company has a broad portfolio of products that address challenging medical conditions and significant clinical needs across two major markets, neuro and peripheral vascular. Penumbra sells its products to hospitals primarily through its direct sales organization in the U.S., most of Europe, Canada and Australia, and through distributors in select international markets. Penumbra, Penumbra System and the Penumbra logo are trademarks of Penumbra, Inc. For further information, please visit www.penumbrainc.com.

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