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Open Monoclonal Technology and Recombinant Antibody Technology Announce OmniRa™ Scientific Publication


1/22/2013 9:51:44 AM

PALO ALTO, Calif. & CAMBRIDGE, England--(BUSINESS WIRE)--Today, Open Monoclonal Technology, Inc. (OMT) and Recombinant Antibody Technology, Ltd (RAT) announced a publication about OmniRat™ in the Journal of Immunology (www.jimmunol.org/content/early/2013/01/09/jimmunol.1203041). The publication by scientists from OMT, RAT and Pfizer is entitled “High-Affinity IgG Antibodies Develop Naturally in Ig- Knockout Rats Carrying Germline Human IgH/Igk/Igl Loci Bearing the Rat CH Region” and covers eighteen months of close collaboration between the teams. The manuscript describes a comprehensive comparison of wild type animals with OmniRat, the first genetically engineered rat to generate fully human antibody specificities. While there have been numerous transgenic mice expressing human antibodies, this is the first genetic engineering project that resulted in an animal that makes antibodies with fully human idiotypes as well as wild type animals make their own antibodies.

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