ONI BioPharma to Commence Trading on the Over-the-Counter Bulletin Board on Monday, December 22, 2008; ONI BioPharma to Post Audio Release on Friday, December 19, 2008

ALACHUA, Fla.--(BUSINESS WIRE)--Oragenics, Inc. d/b/a ONI Biopharma Inc. (the "Company" or "ONI" AMEX:ONI), an American biopharmaceutical company that has developed broad-based technologies in oral care, antibiotics, diagnostics and weight control, today announced that commencing Monday, December 22, 2008, quotations for the Company's shares will be available on the Over-the-Counter (OTC) Bulletin Board. To the extent a change in the Company's trading symbol occurs the Company expects to issue a press release announcing the new symbol. The transition to the OTC is expected to be seamless to investors. Investors should be able to trade their ONI shares through their brokers in the same manner as they had been prior to this date.