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OncoGenex Pharmaceuticals Inc. (OGXI) Retrenches, And Searches For Answers, After Failed Trial


5/22/2014 7:45:55 AM

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There are several harsh lessons to be learned in drug development, and OncoGenex learned perhaps the most brutal one of all: a knockout Phase 2 trial doesn’t guarantee a thing in Phase 3. Earlier this year, Bothell, WA- and Vancouver, BC-based OncoGenex (NASDAQ: OGXI) thought it had everything figured out. Its RNA-based cancer drug, custirsen, seemed to be disarming a protein thought to help tumors resist chemotherapy. Take out that protein, and custirsen would make chemotherapy more effective. Patients should live longer. And in fact, patients in Phase 2 trials for prostate cancer on custersin and chemo lived months longer than the average for patients with similar diagnoses and chemo alone.

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