Of Mice and Men: Modelling Chromosomal Instability in Cancer, Wellcome Trust Sanger Institute Study
A hallmark of human cancer is highly disorganised, unstable genomes driven by alterations in multiple pathways. Single gene mouse models of cancer development have, in general, not faithfully recapitulated this facet of human disease leading to restrictions on their utility in comparative cancer genomics. Work reported by researchers in Nature, show that appropriately modelled instability in the mouse can provide a valuable approach for using comparative genetics to further our understanding of human cancer.