Non-Brain Penetrant CB1 Antagonists from Jenrin Discovery Show Beneficial Effects in Treating Diabetes and Obesity

PHILADELPHIA--(BUSINESS WIRE)--Research shows that proprietary non-brain penetrant cannabinoid subtype 1 (CB1) receptor antagonists developed by Jenrin Discovery are able to produce metabolically favorable effects in peripheral tissues, including fat and liver. The research also showed for the first time that these results are achievable when CB1 antagonists are modified so that they do not cross the blood-brain barrier, thereby reducing the risk of psychiatric side effects associated with the use of CB1 antagonists that are brain-penetrant. Results were presented in a plenary session at the 2008 Annual Scientific Meeting of the Obesity Society.