Nimbus Discovery IRAK4 Inhibitors Demonstrate Synergistic Effects With BTK Inhibitor Ibrutinib

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Nimbus Discovery LLC, a biotechnology company discovering novel medicines against exciting but previously inaccessible disease targets, will present preclinical data today that show that the novel Nimbus IRAK4 inhibitors (ND-2110 and ND-2158) when combined with the Bruton’s tyrosine kinase (BTK) inhibitor, ibrutinib, work synergistically to induce selective cell death in hematological tumors with the activating MyD88 mutation. This genetically-defined patient population can be identified in the clinic prior to treatment increasing the potential for positive response. These findings were generated in collaboration with Louis M. Staudt, M.D., Ph.D., Head, Molecular Biology of Lymphoid Malignancies Section at the National Cancer Institute (NCI).