BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

New Collaboration Between TAP Biosystems and University College London - to Develop Biomimetic 3D Cancer Models for Use in Drug Discovery


10/4/2012 10:39:48 AM

04 October 2012 -- TAP Biosystems, a leading supplier of innovative cell culture systems and consumables for life science applications, is pleased to announce a new collaboration with researchers at University College London (UCL) in the UK to develop solid tumour tissue models using its RAFT 3D cell culture system for use in drug discovery applications.

The three way collaboration, between TAP Biosystems and researchers on two UCL sites at the Division of Surgery and Interventional Science, will focus on developing technology to generate advanced 3D cancer tissue models for use in research and drug discovery. Their aim is to use TAP’s RAFT™ (Real Architecture for 3D Tissue™) technology to reproduce solid tumour micro architecture, by seeding co-cultures of cancer cells, fibroblasts and endothelial cells into a collagen gel. With the correct conditions, fibroblasts aggregate around the cancer cells to form connective tissue, and the endothelial cells fuse to form lumens, producing angiogenic growth factor and rudimentary vasculature, so that the final co-culture has many of the features and behaviour of a solid tumour.

Dr Marilena Loizidou, Senior Lecturer, Division of Surgery and Interventional Science at UCL explained:”Our ultimate aim is to engineer reproducible 3D tissues to test the efficacy of compounds and biologics to treat solid tumours in diseases such as breast, bowel and bladder cancer. By engineering these types of tissues, we’ll have a far reaching impact on translational research, as we could more readily tease out the mechanisms of why drugs do or don’t act effectively on tumours.”

Dr Umber Cheema, Research Fellow at the Division of Surgery and Interventional Science at UCL added: “When making 3D cancer tissues it is very difficult to do this in a controlled, reproducible way, and we need help making the tissue formation process consistent for pharma and biotech use. TAP Biosystems is a company that has a proven background, as well as a progressive vision. We believe utilising the RAFT platform is the best way to make our science relevant and are very pleased to be partnering with TAP on this project.”

Dr Rosemary Drake, CSO at TAP Biosystems said: “We are delighted to be extending our collaborative partnerships at UCL to include a new application of the RAFT process. We look forward to working together with Dr Marilena Loizidou and Dr Umber Cheema’s teams of experts to develop novel 3D human tumour models that reproduce the cells’ in vivo environment. Using this approach to create more realistic and complex models, should mean that data are more robust and relevant and drug screening becomes more efficient. This could result in significant cost savings, and, more importantly, may contribute to reducing the amount of pre-clinical animal studies required for testing new oncology therapies.”

For further information, please contact:

Matthew Walker, Head of Communications

York Way, Royston, Hertfordshire, SG8 5WY, UK

Tel: +44 1763 227200 Fax: +44 1763 227201



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES