New Application Note for TAP Biosystems’s ambr15 Micro Bioreactors Provides Tips On How To Maximise Data Collection With Minimum Sample Volume And Smart Sampling Regimes
Cambridge, UK: TAP Biosystems (now part of the Sartorius Stedim Biotech Group), a leading supplier of innovative cell culture and fermentation systems for life science applications, today announced the availability of a new technical note on managing sample volume for its ambr15™ micro bioreactor system. This note will provide an invaluable guide for scientists to obtain critical data using easy-to-implement sampling regimes and analytical techniques, thus maximising the capabilities of the ambr15 to make process development for biologics faster and less costly.
The new note reflects commonly employed ‘best practice’ for successful sampling strategies as implemented in major biopharmaceutical firms using ambr15 in their process development workflow. The technical note provides advice on how low volume analysers can be effectively used with the ambr15 and explains the sample types that can be automatically diluted using the ambr15’s liquid handling capabilities, enabling scientists to rapidly generate accurate process development results from small sample volumes.
The note also details how to intelligently maximize data generation by reducing sampling frequency and prioritising assays, as well as explaining how to set up replicate cultures to increase volume available for sampling. These include a worked example of a 14 day ambr15 bioprocess and an example experimental layout for an optimum sampling regime of replicates. Using the details in this application note will allow bioprocess scientists to reduce their reliance on shake flasks and bench top bioreactors, reducing the amount of media and reagents required and saving many months of scale-up process development work.
The methods are available in a technical application note, which can be requested via the link: http://www.tapbiosystems.com/tap/cell_culture/ambr_technotereq.asp
Dr Barney Zoro, ambr15 Product Manager at TAP Biosystems stated: "Many traditional analysers are not designed for use with micro scale bioreactors, so managing the culture volume when running ambr15 experiments requires planning. To make it as simple as possible for scientists to operate their ambr15 processes most effectively and get the key analytical data points that they need, we have distilled intelligent sampling strategies into this one handy application note, many of which have now been implemented by ambr15 users in major pharma companies.”
Zoro continued: “Utilising the methods in this technical note will help scientists to accurately select the right cell lines and optimise their bioprocess parameters in weeks rather than months, using less media, reagents and staff time. This will ultimately enable ambr15 micro bioreactor users to rapidly develop robust, cost-effective manufacturing processes and affordable biologics.”
For Further Information Contact:
Michaela McAdam, Marketing Communications Manager, TAP Biosystems, York Way, Royston, Hertfordshire, SG8 5WY, UK. Tel: +44 (0) 1763 227200 Fax: +44 (0) 1763-227201
Email: Michaela.mcadam@tapbiosystems.com Web: www.tapbiosystems.com Twitter: @TAPBiosystems
Editor Contact:
Dr Sue Pearson, Director, International Science Writer, PO Box 170, Hitchin, Hertfordshire, SG5 3GD, UK. Tel/Fax + 44 (0) 1462-635327 Email: sue.pearson@internationalsciencewriter.com
Web: www.internationalsciencewriter.com Twitter: @isciencewriter
Note to Editors
About TAP Biosystems
TAP Biosystems (now part of the Sartorius Stedim Biotech Group) is a leading global provider of automated cell culture and fermentation systems for life science research, development and production. TAP's systems are in use worldwide at pharmaceutical, biotechnology and academic laboratories, supporting bioprocess development and GMP manufacture of biologics and cell therapies, as well as discovery and stem cell research programmes.
Founded in 1987, the company has offices in the UK and USA, and an extensive network of distributors in Europe and Asia offering pre- and post-sales support.
www.tapbiosystems.com
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