Neovacs SA: Recently Published Data Demonstrate Sustained But Reversible Therapeutic Efficacy Of The TNFa Kinoid In A Validated Model Of Rheumatoid Arthritis

Arthritis Research -- Passive blockade of tumor necrosis factor-alpha (TNF-a) has demonstrated high therapeutic efficiency in chronic inflammatory diseases, such as rheumatoid arthritis, although some concerns remain such as occurrence of resistance and high cost. These limitations prompted investigations of an alternative strategy to target TNF-a. This study sought to demonstrate a long-lasting therapeutic effect on established arthritis of an active immunotherapy to human (h) TNF-a and to evaluate the long-term consequences of an endogenous anti-TNF-a response.