BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

N30 Pharma Announces Publication of S-Nitrosoglutathione Reductase Small Molecule Inhibitor Chemistry and Development


3/14/2011 8:21:49 AM

BOULDER, CO--(Marketwire - March 14, 2011) -

N30 Pharmaceuticals LLC (N30 Pharma) today announced publication of a paper titled, "Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases" in the Journal ACS Medicinal Chemistry Letter. This paper details the structure-based optimization of potent small molecule inhibitors of the enzyme S-nitrosoglutathione reductase (GSNOR). The report focuses on the lead chemical series which generated N30 N6022, a first in class GSNOR inhibitor currently in Phase 1b/2a trials for the treatment of asthma.

The publication can be accessed at: http://pubs.acs.org/journal/amclct

GSNOR breaks down S-nitrosoglutathione (GSNO), and as such is an important regulator of the body's pool of GSNO. In the lung, GSNO likely plays an important role in maintaining normal respiratory function through its influence on bronchial tone and anti-inflammatory effects. In asthmatics, GSNOR up-regulation and decreased GSNO levels have been shown to contribute to respiratory disease, and genetic variants of GSNOR have been correlated with disease susceptibility and poor response to therapy. GSNO has also been found to be important in the gastrointestinal and cardiovascular systems, as well as the regulating the control of breathing. GSNOR inhibitors are novel drug candidates, and represent a new approach to treating asthma and other inflammatory diseases.


Contact Information

Email: Email Contact

Gary J. Rosenthal, PhD
EVP Discovery Research
(720) 945-7712

Charles Scoggin, MD
CEO
(720) 945-7721

Digg this    Bookmark with del.icio.us    Add to Newsvine

Technorati:



Read at BioSpace.com

   
Asthma

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES