Monoclonal Antibodies Market For Gastric And Esophageal Cancers To Double By 2019: GBI Research

NEW YORK (GBI Research), 17 January 2014 -- Due to favorable market conditions in terms of US pricing structures and the anticipated approval of a number of late-stage pipeline drugs, the market value for monoclonal antibodies (mAbs) in gastric and esophageal cancer treatment is expected to double by 2019, according to a new report from business intelligence provider GBI Research.

The company’s latest report* forecasts that the market for mAbs in gastric cancer will grow from $256m in 2012 to $501m by 2019, at a Compound Annual Growth Rate (CAGR) of 10%, while the mAbs market for esophageal cancer is expected to climb from $137m in 2012 to $265m by 2019, at a CAGR of 9.9%.

Currently, there is only one mAb — Herceptin — available for the two indications. Primarily marketed for breast cancer, Herceptin gained approval from the US Food and Drug Administration for the treatment of gastric and esophageal cancers in 2010. However, its patent is expected to expire in the European Union in 2014 and in the US by 2019.

Dominic Trewartha, Analyst for GBI Research, says: “Overall, Herceptin is able to improve survival times to a significant extent when compared with chemotherapy alone, without adding a substantial amount of side effects or safety concerns in Human Epidermal growth factor Receptor-2 (HER-2) positive patients. However, its efficacy is not sufficient to bring about a sustained remission in most cases of advanced disease, or to replace conventional chemotherapy completely in earlier stages.”

According to GBI Research, the pipeline for both indications is moderate, with 33 mAbs for gastric cancer and eight for esophageal cancer. The late-stage pipelines also include a number of novel drugs that have shown some clinical and commercial potential. However, none of these products are anticipated to offer significant improvements over existing therapies.

“There is still a need for stronger products with superior efficacy to treat both gastric and esophageal cancers in the metastatic and early settings periods. Also, with a large HER-2 negative patient population that is not eligible for treatment with Herceptin, there is a strong unmet need and opportunity for therapies that are effective in these patients, including those who overexpress HER-2,” Trewartha concludes.

*Monoclonal Antibodies Market in Gastric and Esophageal Cancers to 2019 - Crowded Late-Stage Pipelines and Favorable Market Conditions Encourage Robust Growth

This report gives a comprehensive review of the pipeline for monoclonal antibodies (mAbs) in gastric and esophageal cancers, including individual analysis of a number of late-stage pipeline drugs that are likely to enter the market by 2019. The pipeline is analyzed on the basis of phase distribution, molecule types and molecular targets.

This report was built using data and information sourced from proprietary databases, primary and secondary research, and in-house analysis conducted by GBI Research’s team of industry experts.

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