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MolecularMD Announces Issuance of Patent Covering Methods for Therapeutic Resistance Monitoring in Lung Cancer Patients


12/9/2011 8:59:50 AM

PORTLAND, OR--(Marketwire - December 09, 2011) -

MolecularMD Corp. today announces the issuance of a patent titled "Methods and Compositions for Detecting a Drug Resistant EGFR Mutant." The newly issued U.S. Patent is based on the pioneering work of researchers at Memorial Sloan-Kettering Cancer Center to identify causes of resistance in patients treated with epidermal growth factor receptor (EGFR) targeted therapies erlotinib (Tarceva™) or gefitinib (Iressa™)(1). MolecularMD has exclusively licensed the commercial rights to this intellectual property which covers methods for detecting the EGFR T790M mutation.

"A high proportion of non-small cell lung cancer (NSCLC) patients treated with erlotinib or gefitinib develop the gatekeeper EGFR T790M mutation. Identifying this mutation with our test will support development of promising next-generation EGFR-targeted therapies critical to overcoming resistance," commented Stephane Wong, Chief Scientific Officer of MolecularMD.

The new U.S. Patent, No. 8,067,175, describes methods of detecting the EGFR T790M mutation as it relates to acquired resistance in patients harboring activating EGFR mutations. Monitoring for the emergence of the EGFR T790M mutation will allow for early identification of acquired resistance and prompt treatment intervention.

About EGFR in Lung Cancer
The epidermal growth factor receptor has been identified as a therapeutic target for treatment of solid tumors, as it is involved in proliferation and survival of cancer cells. EGFR is of particular significance in the most common form of lung cancer, non-small cell lung cancer (NSCLC), in which activating mutations of the EGFR gene are key drivers of the disease. Drugs directed at inhibiting the activated EGFR, the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib, have recently joined the arsenal of oncology therapeutics. Despite initial responses to TKI treatment, unfortunately the clinical utility of these first-generation EGFR inhibitors is short-lived due to acquired resistance. In approximately 50% of cases, this acquired resistance is a result of emergence of the T790M mutation in EGFR.

About MolecularMD
MolecularMD Corporation develops and commercializes specialty molecular diagnostics for oncology applications. Its tests are designed to allow appropriate selection, monitoring and management of patients treated with molecularly targeted cancer therapies. MolecularMD's assays incorporate both gold-standard and innovative technologies to provide highly sensitive, standardized, reliable results that support clinical development, regulatory approval, and commercialization of novel anticancer agents. A private company based in Portland, Oregon, MolecularMD was founded by Brian Druker, director of the Knight Cancer Center at Oregon Health & Science University, and Sheridan G. Snyder, entrepreneur and founder of Genzyme Corporation and Upstate Biotechnology.

(1)W. Pao, V. A. Miller, K. A. Politi, G. J. Riely, R. Somwar, M. F. Zakowski, M. G. Kris, H. Varmus, Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Medicine 2, e73 (2005).


MolecularMD Contact:
Katherine Clock
1-877-459-4979
www.molecularmd.com

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