BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

MolecularMD and Ventana Medical Systems, Inc. (VMSI) Reach Collaborative Research Agreement: Limits of Detection and Sensitivity for PTEN Gene Using In-Situ Hybridization and Immunohistochemistry Methods


12/6/2012 10:03:55 AM

PORTLAND, OR--(Marketwire - December 06, 2012) -

MolecularMD, based in Portland, OR, has formed a collaborative research agreement with Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, in support of the PTEN (phosphatase and tensin homolog) study, building upon the ongoing link between research and diagnostic development.

The PTEN gene is a major positive and negative regulator, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. This key signaling component is one of the most frequently mutated proteins in human cancers, resulting in unregulated activation of PI3K signaling and providing irrefutable genetic evidence of the central role of this pathway in tumor growth.

The objective of this study is to determine the correlation between methods for detecting PTEN gene copy number and protein biomarker expression using in-situ hybridization (ISH) methods for gene detection, PTEN Sanger Sequencing for mutational analysis and immunohistochemistry (IHC) methods for protein staining. Brightfield ISH and Sanger Sequencing methods will be compared for detecting gene copy number. These ISH results will be compared to the levels of expression of the PTEN protein detected by immunohistochemistry. The expected result will be an understanding of the analytical validity of Brightfield ISH methods, compared to Sanger Sequencing, and IHC methods for determination of PTEN status.

"MolecularMD's collaboration with Ventana Medical Systems, Inc. links the strengths and innovations of our respective companies to support the shared goal of validating new diagnostic solutions for translational and clinical cancer research," stated Dan Snyder, President and COO.

About MolecularMD
MolecularMD Corporation develops and commercializes specialty molecular diagnostics for oncology applications. Its tests are designed to allow appropriate selection, monitoring and management of patients treated with molecularly-targeted cancer therapies. MolecularMD incorporates gold-standard and innovative technologies in providing its partners with the highest quality results. Assays are designed to meet clinical trial needs, and MolecularMD has appropriate systems and standards in place to enable development of companion diagnostic tests in conjunction with partners' novel anticancer agents. A private company based in Portland, Oregon, MolecularMD was founded by Brian Druker, director of the Knight Cancer Center at Oregon Health & Science University, and Sheridan G. Snyder, entrepreneur and founder of Genzyme Corporation.

www.molecularmd.com


MolecularMD Contact:
Katherine Clock
503-459-4974
Email Contact

MolecularMD
1341 SW Custer Dr.
Portland, OR 97219

T: 1-877-459-4979
Email Contact
www.molecularmd.com

Digg this    Bookmark with del.icio.us    Add to Newsvine

Technorati:



Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES