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Mice With "Humanized" Livers Improve Early Drug Testing, Stanford University School of Medicine Scientists Show



11/1/2012 7:41:08 AM

Stanford University School of Medicine scientists have used bioengineered mice with livers composed largely of human cells to characterize a drug about to enter early-stage clinical development for combating hepatitis C. Tests using the new mouse model accurately predicted significant aspects of the drug's behavior in humans — including its interaction with another drug and the profile of its major breakdown products in the body (called metabolites) — far more accurately than would have been achieved using current methods.

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