Many Proteins Exist in a State of "Disorder" and Yet are Functional, Washington University in St. Louis Study
9/21/2012 7:28:09 AM
Students are taught that a protein’s three-dimensional shape is critical to its function, but it turns out that many proteins exist in a state of “disorder” and yet are functional. If you open any biology textbook to the section on proteins, you will learn that a protein is made up of a sequence of amino acids, that the sequence determines how the chain of amino acids folds into a compact structure, and that the folded protein’s structure determines its function. In other words sequence encodes structure and function derives from structure. But the textbooks may have to be rewritten.
comments powered by